JNK signaling: regulation and functions based on complex protein-protein partnerships

A Zeke, M Misheva, A Reményi… - … and Molecular Biology …, 2016 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Signal integration by JNK and p38 MAPK pathways in cancer development

EF Wagner, ÁR Nebreda - Nature Reviews Cancer, 2009 - nature.com
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

JNK signalling in cancer: in need of new, smarter therapeutic targets

C Bubici, S Papa - British journal of pharmacology, 2014 - Wiley Online Library
The JNKs are master protein kinases that regulate many physiological processes, including
inflammatory responses, morphogenesis, cell proliferation, differentiation, survival and …

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate

KYC Fung, L Cosgrove, T Lockett, R Head… - British Journal of …, 2012 - cambridge.org
Colorectal cancer (CRC) is a leading cause of preventable cancer deaths worldwide, with
dietary factors being recognised as key risk modifiers. Foods containing dietary fibre are …

c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges

MA Bogoyevitch, KRW Ngoei, TT Zhao… - … et Biophysica Acta (BBA …, 2010 - Elsevier
c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …

Targeting innate immunity protein kinase signalling in inflammation

M Gaestel, A Kotlyarov, M Kracht - Nature Reviews Drug Discovery, 2009 - nature.com
Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

L Hui, K Zatloukal, H Scheuch… - The Journal of …, 2008 - Am Soc Clin Investig
JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent
of their involvement in the development of human liver cancers is unknown. Here, we show …

MAPK signaling in inflammation-associated cancer development

P Huang, J Han, L Hui - Protein & cell, 2010 - Springer
Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine
kinases, which are highly conserved in protein structures from unicellular eukaryotic …

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

BD McKinnon, V Kocbek, K Nirgianakis… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Endometriosis, the growth of endometrial tissue outside the uterine cavity, is
associated with chronic pelvic pain, subfertility and an increased risk of ovarian cancer …

ASK1 inhibition: a therapeutic strategy with multi-system benefits

JM Ogier, BA Nayagam, PJ Lockhart - Journal of molecular medicine, 2020 - Springer
Abstract p38 mitogen-activated protein kinases (P38α and β) and c-Jun N-terminal kinases
(JNK1, 2, and 3) are key mediators of the cellular stress response. However, prolonged P38 …