The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people
hospitalized with severe COVID-19 illness has engendered considerable interest in the …

Background. Although vaccine rollout for COVID‐19 has been effective in some countries,
there is still an urgent need to reduce disease transmission and severity. We recently carried …

Importance The National COVID Cohort Collaborative (N3C) is a centralized, harmonized,
high-granularity electronic health record repository that is the largest, most representative …

Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …

Results The final selected studies (n= 24 studies; 32,715 patients) showed significant
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …

Objectives There is conflicting evidence about the efficacy of statin use in regard to clinical
outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and …

Background Statins have anti-inflammatory and immunomodulatory effects that may reduce
the severity of coronavirus disease 2019 (COVID-19), in which organ dysfunction is …

The impact of statins on COVID-19 remains unclear. This study aims to investigate whether
statin exposure assessed both in the population and in well-defined cohorts of COVID-19 …

Purpose Observations studies have shown that prior use of statins is associated with a
reduced risk of adverse clinical outcomes in patients with COVID-19. However, the available …

Background: The majority of US reports of COVID-19 clinical characteristics, disease course,
and treatments are from single health systems or focused on one domain. Here we report …