A Drosophila protein-interaction map centered on cell-cycle regulators
CA Stanyon, G Liu, BA Mangiola, N Patel, L Giot… - Genome biology, 2004 - Springer
Background Maps depicting binary interactions between proteins can be powerful starting
points for understanding biological systems. A proven technology for generating such maps …
points for understanding biological systems. A proven technology for generating such maps …
High‐throughput two‐hybrid analysis: The promise and the peril
S Fields - The FEBS journal, 2005 - Wiley Online Library
The two‐hybrid method detects the interaction of two proteins by their ability to reconstitute
the activity of a split transcription factor, thus allowing the use of a simple growth selection in …
the activity of a split transcription factor, thus allowing the use of a simple growth selection in …
From pull-down data to protein interaction networks and complexes with biological relevance
Motivation: Recent improvements in high-throughput Mass Spectrometry (MS) technology
have expedited genome-wide discovery of protein–protein interactions by providing a …
have expedited genome-wide discovery of protein–protein interactions by providing a …
Increasing specificity in high-throughput yeast two-hybrid experiments
Since its inception, the yeast two-hybrid (Y2H) system has proven to be an efficient system to
identify novel protein–protein interactions. However, Y2H screens are sometimes criticized …
identify novel protein–protein interactions. However, Y2H screens are sometimes criticized …
Unraveling protein networks with power graph analysis
L Royer, M Reimann, B Andreopoulos… - PLoS computational …, 2008 - journals.plos.org
Networks play a crucial role in computational biology, yet their analysis and representation
is still an open problem. Power Graph Analysis is a lossless transformation of biological …
is still an open problem. Power Graph Analysis is a lossless transformation of biological …
Protein complex identification by supervised graph local clustering
Motivation: Protein complexes integrate multiple gene products to coordinate many
biological functions. Given a graph representing pairwise protein interaction data one can …
biological functions. Given a graph representing pairwise protein interaction data one can …
Network medicine: an approach to complex kidney disease phenotypes
AK Pandey, J Loscalzo - Nature Reviews Nephrology, 2023 - nature.com
Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …
more than a century. However, the reductionist approach of characterizing diseases from a …
Microarrays to characterize protein interactions on a whole‐proteome scale
B Schweitzer, P Predki, M Snyder - Proteomics, 2003 - Wiley Online Library
Protein microarrays contain a defined set of proteins spotted and analyzed at high density,
and can be generally classified into two categories; protein profiling arrays and functional …
and can be generally classified into two categories; protein profiling arrays and functional …
Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks
The idea of “date” and “party” hubs has been influential in the study of protein–protein
interaction networks. Date hubs display low co-expression with their partners, whilst party …
interaction networks. Date hubs display low co-expression with their partners, whilst party …
Filtering high-throughput protein-protein interaction data using a combination of genomic features
A Patil, H Nakamura - BMC bioinformatics, 2005 - Springer
Background Protein-protein interaction data used in the creation or prediction of molecular
networks is usually obtained from large scale or high-throughput experiments. This …
networks is usually obtained from large scale or high-throughput experiments. This …