Background Currently, no second-line systemic treatment regimen has been recommended
in advanced biliary tract cancer (BTC). Cumulative clinical evidence showed that systemic …

Genetic alterations in CRC have shown a negative predictive and prognostic role in specific
target therapies. The onset of immunotherapy has also undergone remarkable therapeutic …

Background Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more
frequently in younger women than those with high-grade disease. The current treatment is …

Simple Summary There are limited studies that incorporate genetic/epigenetic alterations
into the assessment of the microsatellite instability (MSI) and mismatch repair (MMR) …

Background We performed a pooled analysis of TRIBE and TRIBE2 studies to assess the
efficacy and safety of the intensification of upfront chemotherapy backbone–from doublets to …

Background POLE and POLD1 proofreading deficiency (POLE/D1pd) define a rare subtype
of ultramutated metastatic colorectal cancer (mCRC; over 100 mut/Mb). Disease-specific …

Background. Alternative splicing (AS) plays a crucial role in regulating the progression of
colorectal cancer (CRC), but its distribution remains to be explored. Here, we aim to …

The recognized importance of microsatellite instability (MSI) in cancer has evolved
considerably in the past 30 years. From its beginnings as a molecular predictor for Lynch …

Purpose In the modern era of precision medicine, next-generation sequencing (NGS) is
employed for a variety of clinical purposes. The aim of this study was to investigate the …

Objectives: Despite recent research highlighting the critical function of RIO kinase 3 (RIOK3)
in a variety of malignancies, a comprehensive evaluation of RIOK3 in human tumors is …