Rethinking antiphospholipid syndrome to guide future management and research
Antiphospholipid syndrome (APS) consists of thrombotic, non-thrombotic and obstetric
clinical manifestations developing in individuals with persistent antiphospholipid antibodies …
clinical manifestations developing in individuals with persistent antiphospholipid antibodies …
Antiphospholipid syndrome pathogenesis in 2023: an update of new mechanisms or just a reconsideration of the old ones?
E Raschi, MO Borghi, F Tedesco, PL Meroni - Rheumatology, 2024 - academic.oup.com
Antibodies against phospholipid (aPL)-binding proteins, in particular, beta 2 glycoprotein I
(β2GPI), are diagnostic/classification and pathogenic antibodies in antiphospholipid …
(β2GPI), are diagnostic/classification and pathogenic antibodies in antiphospholipid …
Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome
A Tambralli, A Harbaugh… - The Journal of …, 2024 - Am Soc Clin Investig
Neutrophil hyperactivity and neutrophil extracellular trap release (NETosis) appear to play
important roles in the pathogenesis of the thromboinflammatory autoimmune disease known …
important roles in the pathogenesis of the thromboinflammatory autoimmune disease known …
Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps
K Kmeťová, E Lonina, S Yalavarthi, JS Levine… - Clinical …, 2023 - Elsevier
Abstract Beta-2 glycoprotein I (β 2 GPI) is a phospholipid-binding plasma protein and
prominent autoantigen in antiphospholipid syndrome (APS). Here, we tested the hypothesis …
prominent autoantigen in antiphospholipid syndrome (APS). Here, we tested the hypothesis …
The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis of Systemic Lupus Erythematosus and Antiphospholipid Syndrome
T Reshetnyak, K Nurbaeva - International Journal of Molecular Sciences, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two related
autoimmune diseases. In recent years, there has been sufficient evidence to suggest that …
autoimmune diseases. In recent years, there has been sufficient evidence to suggest that …
Pregnancy in antiphospholipid syndrome: what should a rheumatologist know?
L Andreoli, F Regola, A Caproli, F Crisafulli… - …, 2024 - academic.oup.com
This review focuses on the management of reproductive issues in women who have
antiphospholipid syndrome (APS) or are carriers of antiphospholipid antibodies (aPL). The …
antiphospholipid syndrome (APS) or are carriers of antiphospholipid antibodies (aPL). The …
Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome
N Müller-Calleja, W Ruf, KJ Lackner - Critical Reviews in Clinical …, 2024 - Taylor & Francis
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the
presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years …
presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years …
Antiphospholipid antibody carriers and patients with quiescent antiphospholipid syndrome show persistent subclinical complement activation
M Zen, M Tonello, M Favaro, T Del Ross… - …, 2024 - academic.oup.com
Objectives Complement activation has been advocated as one mechanism by which aPLs
can induce thrombosis. In patients with catastrophic APS or re-thrombosis, enhanced …
can induce thrombosis. In patients with catastrophic APS or re-thrombosis, enhanced …
T cell involvement in antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by
arterial and venous thrombosis, and obstetric complications in the presence of …
arterial and venous thrombosis, and obstetric complications in the presence of …
NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies
S Bouvier, M Fortier, E Nouvellon, A Olivan… - Journal of Thrombosis …, 2024 - Springer
Background Antiphospholipid antibody syndrome (APS) is an acquired autoimmune
disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy …
disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy …