The common laboratory mouse (Mus musculus, Mus domesticus), the rat and the hamster
are members of the animal order of rodentia. Rodentia are estimated to have first appeared …

Upon vascular injury, activation of factor VII is effected by tissue factor (TD and this reaction
is the primary event in blood coagulation. The TF: FYIIa complex serves to activate factors IX …

Objective—Diurnal variations in levels of factor VII (FVII), FVIII, proteins C and S,
antithrombin, plasminogen activator inhibitor-1, prothrombin fragment F1+ 2, and D-dimers …

Anticoagulant protein C (PC) is important not only for maintenance of normal hemostasis,
but also for regulating the host immune response during inflammation. Because mice with a …

Lung cancer is the leading cause of cancer death. Conventional photodynamic therapy
(PDT) using a nontargeted photosensitizer (ntPDT) is a treatment option for central-and …

Mice doubly heterozygous for a modified tissue factor pathway inhibitor (TFPI) allele (tfpiδ)
lacking its Kunitz-type domain-1 (TFPI+/δ) and for a deficiency of the factor VII gene (FVII+/–) …

The circadian clock, influencing many biological processes, has been demonstrated to
modulate levels of specific coagulation factors, but its impact on the coagulation efficiency is …

Inactivation of specific genes in mammals by gene targeting has accelerated our ability to
determine gene function. Nearly all genes involved in the blood coagulation system have …

Introduction 2.1. Structure of Protein C 2.2. Function of Protein C 2.3. The Protein C Gene
2.4. Human PC Deficiencies 2.4. 1. Single PC Deficiencies 2.4. 2. Compound PC …

To identify the 5′ sequences of the murine coagulation factor VII (fVII) gene that resulted in
its efficient transcription, a variety of 5′-flanking sequences up to 7 kilobase pairs upstream …