Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

The brain derived neurotrophic factor (BDNF) is a crucial neuromodulator in pain
transmission both in peripheral and central nervous system (CNS). Despite evidence of a …

Background Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve
over a low quality of life brought about by chronic pain. In our previous studies, we …

The traditional medicinal mushroom Hericium erinaceus is known for enhancing peripheral
nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity. Here …

Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …

Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter of neurite
growth, a finding that has led to an ongoing exploration of this neurotrophin as a potential …

The management of neuropathic pain is still a major challenge because of its
unresponsiveness to most common treatments. Curcumin has been reported to play an …

After spinal cord injury (SCI), tissue engineering scaffolds offer a potential bridge for
regeneration across the lesion and support repair through proregenerative signaling. Ideal …

Depression and anxiety commonly occur in chronic pain states and the coexistence of these
diseases worsens outcomes for both disorders and may reduce treatment adherence and …