DNA damage repair pathways in prostate cancer: a narrative review of molecular mechanisms, emerging biomarkers and therapeutic targets in precision oncology

IM Grypari, V Tzelepi, K Gyftopoulos - International Journal of Molecular …, 2023 - mdpi.com
Prostate cancer (PCa) has a distinct molecular signature, including characteristic
chromosomal translocations, gene deletions and defective DNA damage repair …

Exploring the integration of nanotechnology in the development and application of biosensors for enhanced detection and monitoring of colorectal cancer

A Hajjafari, S Sadr, A Rahdar, M Bayat… - Inorganic Chemistry …, 2024 - Elsevier
As the third most severe cancer in the world, colorectal cancer (CRC) is of high concern to
global health concerns. Aging, unhealthy lifestyles, and genetic factors contribute to CRC …

Diagnostic performance of immunohistochemistry compared to molecular techniques for microsatellite instability and p53 mutation detection in endometrial cancer

S Streel, A Salmon, A Dheur, V Bours, N Leroi… - International Journal of …, 2023 - mdpi.com
Molecular algorithms may estimate the risk of recurrence and death for patients with
endometrial cancer (EC) and may impact treatment decisions. To detect microsatellite …

A 39 kb structural variant causing Lynch Syndrome detected by optical genome mapping and nanopore sequencing

PM Bjørnstad, R Aaløkken, J Åsheim… - European Journal of …, 2024 - nature.com
Lynch Syndrome (LS) is a hereditary cancer syndrome caused by pathogenic germline
variants in one of the four mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2. It …

Tumor Testing and Genetic Analysis to Identify Lynch Syndrome Patients in an Italian Colorectal Cancer Cohort

A Pantaleo, G Forte, F Cariola, AM Valentini, C Fasano… - Cancers, 2023 - mdpi.com
Simple Summary Lynch syndrome (LS) is an inherited genetic condition caused by germline
mutations in DNA mismatch repair (MMR) genes. It is associated with a predisposition to …

Understanding the Genetic Landscape of Pancreatic Ductal Adenocarcinoma to Support Personalized Medicine: A Systematic Review

A Pantaleo, G Forte, C Fasano, M Lepore Signorile… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with
high mortality. Most patients present with an advanced stage of the disease, highlighting the …

The Epithelial to Mesenchymal Transition in Colorectal Cancer Progression: The Emerging Role of Succinate Dehydrogenase Alterations and Succinate Accumulation

M Turano, R Vicidomini, F Cammarota, V D'Agostino… - Biomedicines, 2023 - mdpi.com
Colorectal cancer (CRC) stands as the third most significant contributor to cancer-related
mortality worldwide. A major underlying reason is that the detection of CRC usually occurs at …

Germline Variants in MLH1 and ATM Genes in a Young Patient with MSI-H in a Precancerous Colonic Lesion

A Nolano, GB Rossi, V D'Angelo, R Liccardo… - International Journal of …, 2023 - mdpi.com
Lynch syndrome (LS) is an autosomal dominant inherited disorder that primarily
predisposes individuals to colorectal and endometrial cancer. It is associated with …

Nanoliposome‐loaded phenolics from Salvia leriifolia Benth and its anticancer effects against induced colorectal cancer in mice

NS Nasrabadi, A Vedad, K Asadi… - Biotechnology and …, 2024 - Wiley Online Library
Colon cancer is one of the leading causes of death among various types of cancer. Despite
the significant progress made in cancer treatment, chemotherapy resistance and various …

Biopsie colique et pathologie néoplasique épithéliale en pratique

D Chatelain - Revue Francophone des Laboratoires, 2023 - Elsevier
Résumé Cette mise au point sur les tumeurs épithéliales coliques permet d'aborder la prise
en charge de ces lésions par les pathologistes, les caractéristiques anatomopathologiques …