Aims Statin intolerance (SI) represents a significant public health problem for which precise
estimates of prevalence are needed. Statin intolerance remains an important clinical …

Background: Statins are the most commonly prescribed agents for hypercholesterolemia
because of their efficacy and tolerability. As the number of patients in need of statin therapy …

Cholesterol, an essential molecule for cell structure, function, and viability, plays crucial
roles in the development, progression, and survival of cancer cells. Earlier studies have …

The concentration of high density lipoprotein-cholesterol (HDL-C) has been found
consistently to be a powerful negative predictor of premature coronary heart disease (CHD) …

Background: Statin therapy has been found to produce substantial reductions in low-density
lipoprotein cholesterol (LDL-C) levels, resulting in a reduced risk for cardiovascular events …

HDL is a lipoprotein that plays a central role in reverse cholesterol transport (RCT). Hypo-
HDL-cholesterolemia has long been recognized as a strong and independent risk factor for …

Drug Class Review HMG-CoA Reductase Inhibitors (Statins) and Fixed-dose Combination
Products Containing a Statin Page 1 Drug Class Review HMG-CoA Reductase Inhibitors (Statins) …

Background This represents the first update of this review, which was published in 2012.
Atorvastatin is one of the most widely prescribed drugs and the most widely prescribed statin …

BACKGROUND:: The available statins exhibit differences in the potency with which they
alter serum lipid levels. OBJECTIVE:: Meta-analyses were conducted to assess the relative …

Programmed cell death 1 ligand 2 (PD-L2), a member of the B7 immune checkpoint protein
family, emerges as a crucial player in immune modulation. Despite its functional overlap with …