Application of radiation omics in the development of adverse outcome pathway networks: an example of radiation-induced cardiovascular disease

O Azimzadeh, S Moertl, R Ramadan… - … Journal of Radiation …, 2022 - Taylor & Francis
Background Epidemiological studies have indicated that exposure of the heart to doses of
ionizing radiation as low as 0.5 Gy increases the risk of cardiac morbidity and mortality with …

Early molecular markers for retrospective biodosimetry and prediction of acute health effects

M Abend, WF Blakely, P Ostheim… - Journal of …, 2022 - iopscience.iop.org
Radiation-induced biological changes occurring within hours and days after irradiation can
be potentially used for either exposure reconstruction (retrospective dosimetry) or the …

Lung transcriptome of nonhuman primates exposed to total-and partial-body irradiation

NN Vellichirammal, S Sethi, S Pandey, J Singh… - … Therapy-Nucleic Acids, 2022 - cell.com
The focus of radiation biodosimetry has changed recently, and a paradigm shift for using
molecular technologies of omic platforms in addition to cytogenetic techniques has been …

RENEB Inter-laboratory comparison 2021: Inter-assay comparison of eight dosimetry assays

M Port, JF Barquinero, D Endesfelder… - Radiation …, 2023 - meridian.allenpress.com
Tools for radiation exposure reconstruction are required to support the medical management
of radiation victims in radiological or nuclear incidents. Different biological and physical …

EPR biodosimetry: challenges and opportunities

HM Swartz, AB Flood - Radiation Protection Dosimetry, 2023 - academic.oup.com
This paper briefly examines electron paramagnetic resonance (EPR) techniques to measure
dose from exposure to external radiation, assessing their current status, potential future uses …

Transcriptome profile changes in the jejunum of nonhuman primates exposed to supralethal dose of total-or partial-body radiation

NN Vellichirammal, S Sethi, N Avuthu, SY Wise… - BMC genomics, 2023 - Springer
The risk of exposure of the general public or military personnel to high levels of ionizing
radiation from nuclear weapons or radiological accidents is a dire national security matter …

Development of biomarkers for radiation biodosimetry and medical countermeasures research: Current status, utility, and regulatory pathways

MM Satyamitra, AL DiCarlo, BA Hollingsworth… - 2022 - meridian.allenpress.com
Biomarkers are important indicators of biological processes in health or disease. For this
reason, they play a critical role in advanced development of radiation biodosimetry tools and …

Gene expression for biodosimetry and effect prediction purposes: promises, pitfalls and future directions–key session ConRad 2021

P Ostheim, SA Amundson, C Badie… - … journal of radiation …, 2022 - Taylor & Francis
Purpose In a nuclear or radiological event, an early diagnostic or prognostic tool is needed
to distinguish unexposed from low-and highly exposed individuals with the latter requiring …

Integrating evolutionarily conserved mechanism of response to radiation for exploring novel Caenorhabditis elegans radiation-responsive genes for estimation of …

L Zhao, Z Li, B Huang, D Mi, D Xu, Y Sun - Chemosphere, 2024 - Elsevier
During space exploration, space radiation is widely recognized as an inescapable perilous
stressor, owing to its capacity to induce genomic DNA damage and escalate the likelihood of …

Serum RNA biomarkers for predicting survival in non-human primates following thoracic radiation

JM May, U Shankavaram, MA Bylicky, S Chopra… - Scientific Reports, 2022 - nature.com
In a mass radiation exposure, the healthcare system may rely on differential expression of
miRNA to determine exposure and effectively allocate resources. To this end, miRNome …