In this review, we describe the experimental paradigms used in preclinical studies to unravel
the histaminergic brain circuits that modulate the formation and retrieval of memories …

ALS currently remains a challenge despite many efforts in performing successful clinical
trials and formulating therapeutic solutions. By learning from current failures and striving for …

The histamine H3 receptor (H3R) represents a highly attractive drug target for the treatment
of various central nervous system disorders, but the discovery of novel H3R targeting …

Abstract Design and development of multitarget-directed ligands (MTDLs) has become a
very important approach in the search of new therapies for Alzheimer's disease (AD). In our …

Alzheimeŕs disease (AD) is the most prominent neurodegenerative disorder with high
medical need. Protein-protein-interactions (PPI) interactions have a critical role in AD where …

Alzheimer's disease (AD) is a neurodegenerative disorder, for which there is no effective
cure. Current drugs only slow down the course of the disease, and, therefore, there is an …

The histamine H 3 receptor is a G protein-coupled receptor (GPCR) drug target that is highly
expressed in the CNS, where it acts as both an auto-and hetero-receptor to regulate …

A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved
to be potent histamine H 3 receptor (H 3 R) ligands in the nanomolar concentration range …

A cation current that slowly activates upon membrane hyperpolarization was detected in a
variety of excitable cells including neurons and cardiac pacemaker cells in the late 1970s …

Abstract Histamine H 3 receptor (H 3 R) is largely expressed in the CNS and modulation of
the H 3 R function can affect histamine synthesis and liberation, and modulate the release of …