The beneficial roles of SIRT1 in neuroinflammation‐related diseases
F Jiao, Z Gong - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …
Cellular innate immunity: an old game with new players
G Gasteiger, A D'osualdo, DA Schubert… - Journal of innate …, 2017 - karger.com
Innate immunity is a rapidly evolving field with novel cell types and molecular pathways
being discovered and paradigms changing continuously. Innate and adaptive immune …
being discovered and paradigms changing continuously. Innate and adaptive immune …
The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases
J Lee, DH Hyun - Antioxidants, 2023 - mdpi.com
Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …
Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom
CMA Rego, AF Francisco, CN Boeno, MV Paloschi… - Scientific Reports, 2022 - nature.com
Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake
species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen …
species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen …
Interactions between the gut microbiota and the host innate immune response against pathogens
HY Cheng, MX Ning, DK Chen, WT Ma - Frontiers in immunology, 2019 - frontiersin.org
The mammalian intestine is colonized by over a trillion microbes that comprise the “gut
microbiota,” a microbial community which has co-evolved with the host to form a mutually …
microbiota,” a microbial community which has co-evolved with the host to form a mutually …
Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
Anti-inflammatory therapeutic mechanisms of natural products: insight from rosemary diterpenes, carnosic acid and carnosol
S Habtemariam - Biomedicines, 2023 - mdpi.com
Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …
Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases
Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …
studies showed that bats have altered inflammasomes, which are central players in aging …
Specific NLRP3 inflammasome assembling and regulation in neutrophils: relevance in inflammatory and infectious diseases
The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …
TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles
F Ibáñez, J Montesinos, JR Ureña-Peralta… - Journal of …, 2019 - Springer
Background Current evidence indicates that extracellular vesicles (EVs) participate in
intercellular signaling, and in the regulation and amplification of neuroinflammation. We …
intercellular signaling, and in the regulation and amplification of neuroinflammation. We …