Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Innate immunity is a rapidly evolving field with novel cell types and molecular pathways
being discovered and paradigms changing continuously. Innate and adaptive immune …

Iron is essential for life. Many enzymes require iron for appropriate function. However,
dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species …

Abstract Convulxin (CVX), a C-type lectin-like protein isolated from the venom of the snake
species, Crotalus durissus terrificus, stimulates platelet aggregation by acting as a collagen …

The mammalian intestine is colonized by over a trillion microbes that comprise the “gut
microbiota,” a microbial community which has co-evolved with the host to form a mutually …

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Carnosic acid (CA) and carnosol (CAR) are two major diterpenes of the rosemary plant
(Rosmarinus officinalis). They possess a phenolic structural moiety and are endowed with …

Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the
activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates …

Background Current evidence indicates that extracellular vesicles (EVs) participate in
intercellular signaling, and in the regulation and amplification of neuroinflammation. We …