Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …

Continuous manufacturing is widely used for the production of commodity products.
Currently, it is attracting increasing interest from the pharmaceutical industry and regulatory …

A continuous tubular crystallizer system with an inner diameter of 2.0 mm and an overall
length of 27 m was used to generate acetylsalicylic acid seeds in situ from ethanolic solution …

Abstract Process Analytical Technology (PAT) has revolutionized pharmaceutical
manufacturing by providing real-time monitoring and control capabilities throughout the …

Online microscopy has received much attention in the field of crystal shape control over
recent years, since commonly used measurement techniques cannot provide enough …

A synthetic image analysis strategy is proposed for in-situ crystal size measurement and
shape identification for monitoring crystallization processes, based on using a real-time …

Although previous research demonstrated improved flowability, packing, fluidization, etc. of
individual powders via nanoparticle dry coating, none considered its impact on very low …

Besides size and polymorphic form, crystal shape takes a central role in engineering
advanced solid materials for the pharmaceutical and chemical industries. This work …

Continuous small-scale production is currently of utmost interest for fine chemicals and
pharmaceuticals. For this purpose, equipment and process concepts in consideration of the …