Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While
there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate …

Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on
inflammation and play a key role in the regulation of immune responses. They affect virtually …

The importance of reactive oxygen species (ROS) in vascular physiology and pathology is
becoming increasingly evident. All cell types in the vascular wall produce ROS derived from …

Growing evidences suggest a role of oxidative stress in hypertension and cardiac
hypertrophy. The fructose (60%)-fed rat represents a model of metabolic syndrome …

Objective—Vascular NADPH oxidases (Noxes) have been implicated in cardiovascular
diseases; however, the importance of individual Nox homologues remains unclear. Here …

Abstract Significance: Metabolic syndrome (MetS) is associated with a greater risk of
diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects …

The RAS (renin–angiotensin system) is integral to cardiovascular physiology; however,
dysregulation of this system largely contributes to the pathophysiology of CVD …

Delivery of antisense oligodesoxynucleotides (ODN) into primary cells is a specific strategy
for research with therapeutic perspectives but transfection-associated difficulties. We …

After the creation of an autogenous lower extremity bypass graft, the vein must undergo a
series of dynamic structural changes to stabilize the arterial hemodynamic forces. These …

The vascular adventitia is activated in a variety of cardiovascular disease states and has
recently been shown to be a barrier to nitric oxide bioactivity. Vascular fibroblasts produce …