Background—Increased vascular oxidative stress induced by hyperlipidemia may alter the
phenotype of vascular smooth muscle (SM) cells and play a crucial role in the progression of …

Increased production of reactive oxygen species (ROS) in the vascular wall is a
characteristic feature of disease states, including atherosclerosis, diabetes and …

Recent interest has focused on superoxide and the upregulation of NADPH oxidase
expression in the aetiology of vein graft failure. Implantation of saphenous vein grafts …

Proliferative modification of vascular smooth muscle cell (vSMC) and impaired bioavailability
of nitric oxide (NO) have both been proposed among the mechanisms linking diabetes and …

Diabetes is associated with increased risk for complications following coronary bypass
grafting (CABG) surgery. Augmented superoxide production plays an important role in …

Zinc is employed as a supplement; however, zinc-related nephropathy is not generally
known. In this study, we investigated zinc-induced renal cell injury using a pig kidney …

Aim Activation of vascular smooth muscle cells (VSMC), a key event in the pathogenesis of
atherosclerosis, is triggered by inflammatory stimuli such as tumour necrosis factor‐alpha …

There is growing evidence that oxidative stress, meaning an excessive production of
reactive oxygen and nitrogen species, underlies many forms of cardiovascular disease. The …

Background Hemodynamic insults at arterial bifurcations are believed to play a critical role
in initiating intracranial aneurysms. Recent studies in a rabbit model indicate that …

OBJECTIVE: Smooth muscle cells (SMCs) from prosthetic vascular grafts secrete higher
levels of collagen than aortic SMCs under basal conditions and during incubation with …