Abstract TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …

Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

The discovery of nuclear export signals (NESs) in a number of proteins revealed the
occurrence of signal-dependent transport of proteins from the nucleus to the …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

Variation in DNA content has been largely ignored as a factor in evolution, particularly
following the advent of sequence-based approaches to genomic analysis. The significant …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted
for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

K'hy do so many hnRNPs exist and what arc their functions? In addition to their role in
transcript packaging, hnRNPs function in a variety of other pathways that influence gene …