We provide direct evidence that pre-mRNA splicing alters mRNP protein composition. Using
a novel in vitro cross-linking approach, we detected several proteins that associate with …

Abstract Beclin 1 encodes a Bcl-2-interacting coiled-coil protein with autophagy and tumor
suppressor function and is monoallelically deleted in 40–75% of sporadic human breast and …

The ubiquitously expressed nonreceptor tyrosine kinase c-Abl contains three nuclear
localization signals, however, it is found in both the nucleus and the cytoplasm of …

The transcription factor c‐Myc is a key regulator of cell proliferation, cell growth,
differentiation, and apoptosis. Deregulated c‐myc expression possesses a high …

One hypothesis that couples infection with autoimmune disease is molecular mimicry.
Molecular mimicry is characterized by an immune response to an environmental agent that …

Components of the pre‐mRNA splicing machinery are localized in interchromatin granule
clusters (IGCs) and perichromatin fibrils (PFs). Here we report the biochemical purification of …

Some proteins are internalized by live cells by a process that does not involve classical
endocytosis and thus gain direct access to the cytoplasm and nucleus. These same proteins …

Gle2p is implicated in nuclear export of poly (A)+ RNA and nuclear pore complex (NPC)
structure and distribution in Saccharomyces cerevisiae. Gle2p is anchored at the nuclear …

▪ Abstract Information can be transferred between the nucleus and the cytoplasm by
translocating macromolecules across the nuclear envelope. Communication of extracellular …

Many viruses replicate in the nucleus of their animal and plant host cells. Nuclear import,
export, and nucleo-cytoplasmic shuttling play a central role in their replication cycle …