The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell
death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated …

In a screen for temperature‐sensitive mutants of Saccharomyces cerevisiae defective for
mRNA export, we previously identified the essential DEAD‐box protein Dbp5p/Rat8p and …

Spinocerebellar ataxia type 2 (SCA2) is a hereditary neurodegenerative disorder caused by
a trinucleotide expansion in the SCA2 gene, encoding a polyglutamine stretch in the gene …

Crm1 of Schizosaccharomyces pombe, a nuclear protein essential for proliferation and
chromosome region maintenance, is a possible target of leptomycin B, an antifungal and …

Mammalian SR proteins are currently thought to function in mRNA export as well as splicing.
They contain multiple phosphorylated serine/arginine (RS/SR) dipeptides. Although SR …

Purpose A male infant developed generalized rash, intestinal inflammation and severe
infections including persistent cytomegalovirus. Family history was negative, T cell receptor …

The Aft1 transcription factor regulates the iron regulon in response to iron availability in
Saccharomyces cerevisiae. Aft1 activates a battery of genes required for iron uptake under …

Recent cell biological observations have provided new insights into how transcription, pre-
mRNA splicing and 3′ processing are organized and coordinated with each other in the …

Nuclear transport is an energy-dependent process mediated by saturable receptors. Import
and export receptors are thought to recognize and bind to nuclear localization signals or …

HIV-1 Rev is an~ 13 kD accessory protein expressed during the early stage of virus
replication. After translation, Rev enters the nucleus and binds the Rev response element …