Mammalian serine and arginine–rich (SR) proteins play important roles in both constitutive
and regulated splicing, and SR protein–specific kinases (SRPKs) are conserved from …

Dendritic cells (DCs), nature's adjuvant, must mature to sensitize T cells. However, although
the maturation process is essential, it is not yet fully understood at the molecular level. In this …

Signal-mediated nuclear transport is a gated process that occurs through a central
transporter element located within the pore complex. The purpose of this investigation was …

ABSTRACT A two-hybrid screening in yeast for proteins interacting with the human hnRNP
A1, yielded a nuclear protein of 917 amino acids that we termed hnRNP A1 a ssociated p …

The autoimmune regulator (AIRE) is a gene where mutations cause the recessively inherited
disorder called autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy …

The mRNA export factor RAE1 (also called GLE2) and the mitotic checkpoint protein BUB3
share extensive sequence homology in yeast as well as higher eukaryotes, although the …

Dendrites are specialized extensions of the neuronal soma that contain components of the
cellular machinery involved in RNA and protein metabolism. Several dendritically localized …

hnRNP A2/B1 proteins are among the most abundant pre-mRNA-binding proteins of
vertebrates and structurally similar to hnRNP A1. We have produced two specific …

Epidermal growth factor (EGF) family of growth factors and their receptors regulate normal
and cancerous epithelial cell proliferation, a process that can be suppressed by antireceptor …

Leukotrienes are important lipid mediators implicated in the regulation of various cellular
processes and in disease states as well as homeostasis. Regulation of leukotriene …