Imaging has become a crucial tool in oncology throughout the course of disease detection
and management, and is an integral part of clinical trials. Anatomical and functional imaging …

For the understanding of functions of proteins in biological and pathological processes,
reporter molecules such as fluorescent proteins have become indispensable tools for …

Activity-based protein profiling (ABPP) is emerging as a mature method for chemically
interrogating the proteome of a cell. This chapter serves to introduce the reader to ABPP by …

An active site mapping of human cathepsin B with dipeptide nitrile inhibitors was performed
for a combinatorial approach by introducing several points of diversity and stepwise …

Cathepsin B is a protease which is able to digest extracellular matrix. It is currently unknown
whether cathepsin B plays a role in cervical cancer development and progression. With Q …

Photochemical internalization (PCI) is a novel, minimally invasive drug delivery technology
that facilitates the delivery of therapeutic molecules into the cytosol of cells. In this work, PCI …

Lysosome trafficking plays a significant role in tumor invasion, a key event for the
development of metastasis. Previous studies from our laboratory have demonstrated that the …

CCL20 or MIP3α is a small~ 8 kDa protein primarily expressed in the liver, colon, prostate,
cervix, and skin. The cellular receptor for CCL20 is CCR6. CCl20 unlike many other …

The synthesis of four new oxorhenium (V) complexes containing the “3+ 1” mixed-ligand
donor set, ReO (SYS) X (where Y= S, py; X= Cl, Br), is described. All of the complexes tested …

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous hematological disorder with
malignant potential controlled by immunological characteristics of the tumor …