Advances in understanding the molecular basis of frontotemporal dementia
R Rademakers, M Neumann… - Nature Reviews Neurology, 2012 - nature.com
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. Until recently, the underlying cause was known in only a minority of cases that were …
basis. Until recently, the underlying cause was known in only a minority of cases that were …
Animal models of Alzheimer's disease and frontotemporal dementia
Insoluble protein aggregates have been linked to Alzheimer's disease (AD) and
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
frontotemporal dementia (FTD). Recent work in transgenic mice has shed light on the role of …
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP …
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP …
The genetics and neuropathology of frontotemporal lobar degeneration
A Sieben, T Van Langenhove, S Engelborghs… - Acta …, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders
characterized by disturbances of behavior and personality and different types of language …
characterized by disturbances of behavior and personality and different types of language …
Alterations of the microRNA network cause neurodegenerative disease
SS Hébert, B De Strooper - Trends in neurosciences, 2009 - cell.com
Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which
function at the post-transcriptional level as a rheostat of the transcriptome and proteome of …
function at the post-transcriptional level as a rheostat of the transcriptome and proteome of …
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
PJ Sampognaro, S Arya, GM Knudsen… - Molecular …, 2023 - Springer
Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to
predispose to neurodegeneration by enhancing protein aggregation. While a subset of α …
predispose to neurodegeneration by enhancing protein aggregation. While a subset of α …
[PDF][PDF] PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue
T Matsubara, A Mita, K Minami, T Hosooka, S Kitazawa… - Cell metabolism, 2012 - cell.com
Adipose tissue secretes adipokines that mediate insulin resistance, a characteristic feature
of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin …
of obesity and type 2 diabetes. By differential proteome analysis of cellular models of insulin …
Opposite microglial activation stages upon loss of PGRN or TREM 2 result in reduced cerebral glucose metabolism
Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial
neurodegenerative phenotype (MG nD) representing two opposite ends. A number of …
neurodegenerative phenotype (MG nD) representing two opposite ends. A number of …
TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers
N Finch, MM Carrasquillo, M Baker, NJ Rutherford… - Neurology, 2011 - AAN Enterprises
Objectives: To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are
associated with frontotemporal lobar degeneration (FTLD) in patients with and without …
associated with frontotemporal lobar degeneration (FTLD) in patients with and without …
FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration
H Urwin, KA Josephs, JD Rohrer, IR Mackenzie… - Acta …, 2010 - Springer
Through an international consortium, we have collected 37 tau-and TAR DNA-binding
protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present …
protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present …