Importance Granulin (GRN) mutations represent one of the most frequent genetic causes of
inherited frontotemporal dementia. The study of asymptomatic carriers ofGRN …

Heterozygous loss-of-function mutations in GRN, the progranulin gene, which result in
progranulin (PGRN) protein haploinsufficiency, are a major cause of frontotemporal lobar …

Progranulin (PGRN) is a growth modulating factor released by a variety of cells. This
molecule has gained the attention of the neuroscience community with recent discoveries of …

Background: Progranulin (PGRN) mutations are associated with different clinical
phenotypes, including frontotemporal lobar degeneration (FTLD), corticobasal syndrome …

Alzheimer's disease (AD) represents a personal tragedy of enormous magnitude, which
imposes a daunting worldwide challenge for health-care providers and society as well. In …

Frontotemporal lobar degeneration (FTLD) is a pathological process characterized by
severe atrophy in the frontal and temporal lobes of the brain (Mackenzie et al., 2011). There …

Mutations in the granulin gene (GRN) cause familial frontotemporal dementia.
Understanding the structural brain changes in presymptomatic GRN carriers would enforce …

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by
degeneration of the fronto temporal lobes and abnormal protein inclusions. It exhibits a …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder marked by mild-
life onset and progressive changes in behavior, social cognition, and language. Loss-of …

Progranulin (PGRN) is a soluble factor that regulates cell proliferation, motility and
inflammation. A role for PGRN in the progression of ovarian and breast cancers is well …