Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …

During the past decade several notable viruses have suddenly emerged from obscurity or
anonymity to become serious global health threats, provoking concern regarding their …

Vaccines are one of the greatest public health achievements and have saved millions of
lives. They represent a key countermeasure to limit epidemics caused by emerging …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
resulted in a global pandemic, prompting unprecedented efforts to contain the virus. Many …

Although one member of the poxvirus family, variola virus, has caused one of the most
devastating human infections worldwide, smallpox, the knowledge gained over the last 30 …

Vaccine development is essential for pandemic preparedness. We previously conducted a
Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East …

Although monkeypox (mpox) has been endemic in Western and Central Africa for 50 years,
it has not received sufficient prophylactic and therapeutical attention to avoid evolving into …

Poxviruses have large DNA genomes, and they are able to infect multiple vertebrate and
invertebrate animals, including humans. Despite the eradication of smallpox, poxvirus …

Introduction: With the increasing number of vaccines and vaccine-preventable diseases, the
pressure to generate multi-valent and multi-pathogen vaccines grows. Combining individual …

Poxviruses are double-stranded DNA viruses that infect insects and a variety of vertebrate
species. The large genomes of poxviruses contain numerous genes that allow these viruses …