Development and standardization of fibrinolysis methods have progressed more slowly than
coagulation testing and routine high‐throughput screening tests for fibrinolysis are still …

Despite improved diagnosis and treatment options, coronary artery disease (CAD) is still the
leading cause of mortality and morbidity worldwide. Established risk factors such as …

Kallikrein (PKa), generated by activation of its precursor prekallikrein (PK), plays a role in the
contact activation phase of coagulation and functions in the kallikrein-kinin system to …

Abnormal fibrin clot structure, in particular increased fibrin fiber density and stiffness and
resistance to fibrinolysis, are reported to be linked to cardiovascular disease (CVD) and a …

Histones released into circulation as neutrophil extracellular traps are causally implicated in
the pathogenesis of arterial, venous, and microvascular thrombosis by promoting …

Background Fibrinogen is the first coagulation protein to reach critical levels during
traumatic haemorrhage. This laboratory study compares paired plasma samples pre-and …

Lysine binding sites (LBSs) of plasminogen (Plg) are essential for maintaining a closed
conformation in circulation and binding to fibrin and cell surface receptors. 1, 2 Upon binding …

Tamoxifen and aromatase inhibitors (AIs) are potent antitumoral agents against breast
cancer. Tamoxifen increases the risk of venous thromboembolism (VTE), but the influence of …

Abstract The American Trial Using Tranexamic Acid (TXA) in Thrombocytopenia (A-TREAT,
NCT02578901) demonstrated no superiority of TXA over placebo in preventing World …

Fibrinogen is the first coagulation protein to reach critically low levels during traumatic
haemorrhage. There have been no differential effects on clinical outcomes between the two …