Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
A review on metal-and metal oxide-based nanozymes: properties, mechanisms, and applications
Q Liu, A Zhang, R Wang, Q Zhang, D Cui - Nano-micro letters, 2021 - Springer
Since the ferromagnetic (Fe 3 O 4) nanoparticles were firstly reported to exert enzyme-like
activity in 2007, extensive research progress in nanozymes has been made with deep …
activity in 2007, extensive research progress in nanozymes has been made with deep …
Recent advances in nanomaterial‐based nanoplatforms for chemodynamic cancer therapy
SL Li, P Jiang, FL Jiang, Y Liu - Advanced Functional Materials, 2021 - Wiley Online Library
Triggered by the endogenous chemical energy in the tumor microenvironment (TME),
chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic …
chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
R Cunningham, CG Hansen - Clinical Science, 2022 - portlandpress.com
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …
Vaccine-like nanomedicine for cancer immunotherapy
Y Yi, M Yu, W Li, D Zhu, L Mei, M Ou - Journal of Controlled Release, 2023 - Elsevier
The successful clinical application of immune checkpoint blockade (ICB) and chimeric
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …
antigen receptor T cells (CAR-T) therapeutics has attracted extensive attention to …
Pembrolizumab for early triple-negative breast cancer
Background Previous trials showed promising antitumor activity and an acceptable safety
profile associated with pembrolizumab in patients with early triple-negative breast cancer …
profile associated with pembrolizumab in patients with early triple-negative breast cancer …
TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …
migration, and the differentiation of a plethora of different cell types. Consistent with these …
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
M Kim, H Mun, CO Sung, EJ Cho, HJ Jeon… - Nature …, 2019 - nature.com
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals,
driving a need for personalised medicine. Here, we report lung cancer organoids and …
driving a need for personalised medicine. Here, we report lung cancer organoids and …
Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma
F Maibach, H Sadozai, SM Seyed Jafari… - Frontiers in …, 2020 - frontiersin.org
Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …
Relationships between immune landscapes, genetic subtypes and responses to immunotherapy in colorectal cancer
E Picard, CP Verschoor, GW Ma… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …