From therapeutic drug monitoring to model‐informed precision dosing for antibiotics
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
[HTML][HTML] A review of population pharmacokinetic analyses of linezolid
E Bandín-Vilar, L García-Quintanilla… - Clinical …, 2022 - Springer
In recent years, many studies on population pharmacokinetics of linezolid have been
conducted. This comprehensive review aimed to summarize population pharmacokinetic …
conducted. This comprehensive review aimed to summarize population pharmacokinetic …
[HTML][HTML] Research priorities towards precision antibiotic therapy to improve patient care
Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …
necessitates novel approaches to therapy. Over the past several decades, investigation of …
Hematological toxicities associated with linezolid therapy in adults: key findings and clinical considerations
D Cattaneo, DJE Marriott… - Expert Review of Clinical …, 2023 - Taylor & Francis
Introduction Linezolid can cause serious adverse effects including thrombocytopenia and
anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult …
anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult …
Emerging therapeutic drug monitoring of anti‐infective agents in Australian hospitals: availability, performance and barriers to implementation
I Sandaradura, JW Alffenaar, MO Cotta… - British journal of …, 2022 - Wiley Online Library
Aims The purpose of the study was to assess the status of emerging therapeutic drug
monitoring (TDM) of anti‐infective agents in Australian hospitals. Methods A nationwide …
monitoring (TDM) of anti‐infective agents in Australian hospitals. Methods A nationwide …
[HTML][HTML] Expert consensus statement on therapeutic drug monitoring and individualization of linezolid
B Lin, Y Hu, P Xu, T Xu, C Chen, L He, M Zhou… - Frontiers in Public …, 2022 - frontiersin.org
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and
individualized treatment have been challenged since its approval. With the in-depth clinical …
individualized treatment have been challenged since its approval. With the in-depth clinical …
LInezolid Monitoring to MInimise Toxicity (LIMMIT1): a multicentre retrospective review of patients receiving linezolid therapy and the impact of therapeutic drug …
C Lau, D Marriott, J Bui, M Figtree, M Gould… - International Journal of …, 2023 - Elsevier
Background Linezolid is a broad-spectrum antimicrobial with limited use due to toxicity. This
study aimed to evaluate linezolid toxicity in a large multicentre cohort. Secondary objectives …
study aimed to evaluate linezolid toxicity in a large multicentre cohort. Secondary objectives …
[HTML][HTML] Tissue penetration of antimicrobials in intensive care unit patients: a systematic review—part II
In patients that are admitted to intensive care units (ICUs), the clinical outcome of severe
infections depends on several factors, as well as the early administration of chemotherapies …
infections depends on several factors, as well as the early administration of chemotherapies …
The Safety and Tolerability of Linezolid in Novel Short-Course Regimens Containing Bedaquiline, Pretomanid, and Linezolid to Treat Rifampicin-Resistant …
T Hasan, E Medcalf, BT Nyang'wa… - Clinical Infectious …, 2024 - academic.oup.com
Background Effectiveness, safety, tolerability, and adherence are critical considerations in
shifting to shorter tuberculosis (TB) regimens. Novel 6-month oral regimens that include …
shifting to shorter tuberculosis (TB) regimens. Novel 6-month oral regimens that include …
Comprehensive guidance for antibiotic dosing in obese adults: 2022 update
L Meng, E Mui, DR Ha, C Stave… - … : The Journal of …, 2023 - Wiley Online Library
Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …
evidence to guide dosing recommendations. We first published guidance for antibiotic …