Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
[HTML][HTML] Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19
L Chen, Q Huang, T Zhao, L Sui, S Wang, Z Xiao… - Redox biology, 2021 - Elsevier
SARS-CoV-2 has caused up to 127 million cases of COVID-19. Approximately 5% of COVID-
19 patients develop severe illness, and approximately 40% of those with severe illness …
19 patients develop severe illness, and approximately 40% of those with severe illness …
[HTML][HTML] microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis
F Ahangari, NL Price, S Malik, M Chioccioli… - JCI insight, 2023 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent
findings have shown a marked metabolic reprogramming associated with changes in …
findings have shown a marked metabolic reprogramming associated with changes in …
Mitochondrial dysfunction in chronic respiratory diseases: implications for the pathogenesis and potential therapeutics
W Zhou, J Qu, S Xie, Y Sun… - Oxidative Medicine and …, 2021 - Wiley Online Library
Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …
Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge
WI Effendi, T Nagano - International Journal of Molecular Sciences, 2022 - mdpi.com
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …
Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1α …
Y Yuan, L Yuan, L Li, F Liu, J Liu, Y Chen, J Cheng… - Stem Cells, 2021 - academic.oup.com
Mesenchymal stem cells (MSCs) have fueled ample translation for treatment of immune-
mediated diseases. Our previous study had demonstrated that MSCs could elicit …
mediated diseases. Our previous study had demonstrated that MSCs could elicit …
Mitochondrial uncoupling protein‐2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age‐associated lung fibrosis
S Rangarajan, ML Locy, D Chanda, A Kurundkar… - Aging …, 2022 - Wiley Online Library
Mitochondrial dysfunction has been associated with age‐related diseases, including
idiopathic pulmonary fibrosis (IPF). We provide evidence that implicates chronic elevation of …
idiopathic pulmonary fibrosis (IPF). We provide evidence that implicates chronic elevation of …
CD38 mediates lung fibrosis by promoting alveolar epithelial cell aging
Rationale: A prevailing paradigm recognizes idiopathic pulmonary fibrosis (IPF) originating
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
from various alveolar epithelial cell (AEC) injuries, and there is a growing appreciation of …
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat
PW Stacpoole, CE McCall - Mitochondrion, 2023 - Elsevier
Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …
Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis
CN D'Alessandro-Gabazza, T Yasuma… - Nature …, 2022 - nature.com
Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute
exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive …
exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive …