Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …

Especially critically ill children are exposed to antibiotic overtreatment, mainly caused by the
fear of missing out a severe bacterial infection. Potential adverse effects and selection of …

Background Critically ill children frequently display observed alterations of pharmacokinetic
(PK) parameters, leading to a reduction in β-lactam concentrations. This study aimed to …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …

Antibiotics are one of the most prescribed drug classes in the pediatric intensive care unit,
yet the incidence of inappropriate antibiotic prescribing remains high in critically ill children …

Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …