Background: Modeling and simulation is increasingly used to study pediatric
pharmacokinetics, but clinical implementation of age-appropriate doses lags behind …

Background The β-lactam antibiotic piperacillin (in combination with tazobactam) is
commonly chosen for empirical treatment of suspected bacterial infections. However …

Objectives To be effective, piperacillin/tazobactam (PTZ) unbound plasma levels need to be
above the minimum inhibitory concentration (MIC) at least 50% of the time between dosing …

Objective To assess whether beta-lactam extended or continuous beta-lactam infusions
(EI/CI) improve clinical outcomes in children with proven or suspected bacterial infections …

Objective Piperacillin/tazobactam (PIP/TAZ) is used for the treatment of lower respiratory
tract bacterial infections in children. This study was performed to evaluate if the current …

Aims Beta‐lactam dose optimization in critical care is a current priority. We aimed to review
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …

The aim of this study was to assess the pharmacokinetic (PK) exposure and clinical toxicity
for three beta-lactams: cefotaxime, piperacillin/tazobactam, and meropenem, depending on …

Resistant gram-negative infections have become increasingly problematic, even in children.
Resistant gram-negative infections in children are associated with a 68% increase in the …

OBJECTIVES Extended-infusion piperacillin/tazobactam (TZP) has been associated with
positive clinical outcomes in adults, but similar data in children are lacking. The objective of …

There has been emerging interest in implementing therapeutic drug monitoring and model-
informed precision dosing of β-lactam antibiotics in critically ill patients, including children …