Purpose Estimated glomerular filtration rate (eGFR) equations reflect kidney function
imprecisely. We aimed to describe whether iohexol-based GFR or eGFRs predict clearance …

Objectives Despite that piperacillin-tazobactam combination is commonly used in critically ill
children, increasing evidence suggests that the current dosing schedules are not optimal for …

Background: In intensive care units intravenous medicine may be used in simultaneous
infusion in the same intravenous site. Sometimes, the physical compatibility and stability of …

Introduction Prolonged infusion with β-lactam antibiotics should theoretically produce a
better clinical efficacy than intermittent infusion in severe infection and infection caused by …

Aims Glomerular filtration rate (GFR) is difficult to assess in critically ill children using gold
standard method and alternatives are needed. This study aimed to determine the most …

The American Heart Association recently published an updated scientific statement on the
management of infective endocarditis in childhood. The recommendations included for …

Evidence on optimal drug dosing in children is lacking, especially in critically ill children.
This vulnerable population is particularly susceptible to overdosing and underdosing due to …

Intravenous β-lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β-lactams are well …

Background: To perform a review describing the pharmacokinetic (PK) parameters and
covariates of interest of the eight first choice β-lactams (BL) antibiotics for treatment of severe …

近年来， 医学危重症领域提出了" 肾功能亢进"（ ARC） 的概念， 将其定义为肾脏对药物的清除
能力增强， 当肌酐清除率> 130 mL/（ min· 1.73 m 2） 时， 即认为患者存在ARC …