The complexity of tobacco smoke leads to some confusion about the mechanisms by which
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …

Much is now known about the carcinogens in cigarette smoke, their conversion to forms that
react with DNA, and the miscoding properties of the resulting DNA adducts that cause the …

Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these …

Frequent losses of chromosome 19p have recently been observed in sporadic lung
adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we …

It is now widely accepted that cancer is attributed to the accumulation of genetic alterations
in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Background: The recently identified RASSF1 locus is located within a 120-kilobase region of
chromosome 3p21. 3 that frequently undergoes allele loss in lung and breast cancers. We …

Identification of the key roles of protein kinases in cancer has led to extensive efforts to
develop kinase inhibitors for the treatment of a wide range of cancers, and more than 30 …

We used overlapping and nested homozygous deletions, contig building, genomic
sequencing, and physical and transcript mapping to further define a∼ 630-kb lung cancer …

Aberrant methylation of CpG islands acquired in tumor cells in promoter regions is one
method for loss of gene function. We determined the frequency of aberrant promoter …