Local communication among mucosal immune cells in patients with celiac disease

J van Bergen, CJ Mulder, ML Mearin, F Koning - Gastroenterology, 2015 - Elsevier
In patients with celiac disease, gluten consumption causes inflammation of the duodenum,
and, to a lesser extent, the proximal jejunum. Immune-dominant gluten peptides are …

Mucosal‐associated invariant T cell receptor recognition of small molecules presented by MR 1

W Awad, J Le Nours, L Kjer‐Nielsen… - … and Cell Biology, 2018 - Wiley Online Library
The major histocompatibility complex (MHC) class‐I related molecule MR 1 is a
monomorphic and evolutionary conserved antigen (Ag)‐presenting molecule that shares the …

[HTML][HTML] Multiple Wheat Genomes Reveal Novel Gli-2 Sublocus Location and Variation of Celiac Disease Epitopes in Duplicated α-Gliadin Genes

G Halstead-Nussloch, T Tanaka, D Copetti… - Frontiers in Plant …, 2021 - frontiersin.org
The seed protein α-gliadin is a major component of wheat flour and causes gluten-related
diseases. However, due to the complexity of this multigene family with a genome structure …

Coeliac disease–from genetic and immunological studies to clinical applications

KEA Lundin, SW Qiao, O Snir… - Scandinavian journal of …, 2015 - Taylor & Francis
Coeliac disease is a common and important gastrointestinal disease. It affects at least 1%,
most Western European populations and in Nordic countries it is even more frequent. It is …

[HTML][HTML] Elaboração e caracterização de cookies sem glúten enriquecidos com farinha de coco: uma alternativa para celíacos

AM Queiroz, RFJ Rocha, DS Garruti… - Brazilian Journal of …, 2017 - SciELO Brasil
Os celíacos encontram dificuldades na adoção de uma dieta totalmente isenta de glúten e
com qualidade nutricional. Para tanto, objetivou-se desenvolver e avaliar cookies sem …

Contemporary celiac disease diagnosis: is a biopsy avoidable?

JR Mills, JA Murray - Current opinion in gastroenterology, 2016 - journals.lww.com
The duodenal biopsy will remain the gold standard for diagnosing celiac disease in a
majority of patients. However, as serology assays evolve and as a greater understanding of …

Classification of intestinal T‐cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status

AD Foers, MS Shoukat, OE Welsh… - The Journal of …, 2021 - Wiley Online Library
In coeliac disease (CeD), immune‐mediated small intestinal damage is precipitated by
gluten, leading to variable symptoms and complications, occasionally including aggressive …

[HTML][HTML] Structural basis for clonal diversity of the public T cell response to a dominant human cytomegalovirus epitope

X Yang, M Gao, G Chen, BG Pierce, J Lu… - Journal of Biological …, 2015 - ASBMB
Cytomegalovirus (CMV) is a ubiquitous and persistent human pathogen that is kept in check
by CD8+ cytotoxic T lymphocytes. Individuals expressing the major histocompatibility …

[HTML][HTML] CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity

L Ciacchi, MDB van de Garde, K Ladell, C Farenc… - Immunity, 2023 - cell.com
CD4+ T cell-mediated immunity against Streptococcus pneumoniae (pneumococcus) can
protect against recurrent bacterial colonization and invasive pneumococcal diseases (IPDs) …

Abrogation of immunogenic properties of gliadin peptides through transamidation by microbial transglutaminase is acyl-acceptor dependent

L Zhou, YMC Kooy-Winkelaar… - Journal of agricultural …, 2017 - ACS Publications
Wheat gluten confers superior baking quality to wheat based products but elicits a pro-
inflammatory immune response in patients with celiac disease. Transamidation of gluten by …