The role of topical insulin in ocular surface restoration: A review

I Krolo, J Behaegel, K Termote, B de Bruyn… - Survey of …, 2024 - Elsevier
Corneal epithelial defects are one of the most common ocular disorders. Restoring corneal
integrity is crucial to reduce pain and regain function, but in cases of neurotrophic or …

[HTML][HTML] The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

M Woronkowicz, H Roberts, P Skopiński - Biology, 2024 - mdpi.com
Simple Summary The corneal epithelium is a protective barrier and refractive structure in the
eye maintained through a complex regenerative process involving the lacrimal gland, tear …

Topical Insulin for Ocular Surface Disease

P Cid-Bertomeu, M Vilaltella, M Martínez… - Journal of Ocular …, 2024 - liebertpub.com
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular
tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a …

[PDF][PDF] The Utilization of Topical Insulin for Ocular Surface Diseases: A Narrative Review

KA Moin, S Pandiri, GN Manion, AH Brown… - Cureus, 2024 - cureus.com
Various etiologies, including diabetic keratopathy (DK), dry eye disease (DED), and
neurotrophic keratopathy (NK), can disrupt corneal homeostasis, exacerbating corneal …

Evaluating the Safety and Efficacy of Topical Insulin for Ocular Disease: A Systematic Review

LJ de Oliveira Andrade, GC Matos de Oliveira… - medRxiv, 2024 - medrxiv.org
Introduction: Ocular surface disorders are prevalent, impacting millions worldwide and
causing significant morbidity. Conventional treatments often fall short in addressing …

Delineating the Therapeutic Potential of Topical Insulin for Ocular Disease Management: A Systematic Review and Meta-Analysis

LJ de Oliveira Andrade, GCM de Oliveira, CS França… - 2024 - researchsquare.com
Background: Ocular surface disorders (OSD) are highly prevalent, affecting millions globally.
While conventional treatments offer some level of success, they often fall short in addressing …

Topical Insulin: A Novel Frontier in Ocular Disease Management-A Systematic Review and Meta-Analysis

LJ de Oliveira Andrade, GCM de Oliveira… - 2024 - researchsquare.com
Abstract Introduction: Background: Ocular surface disorders (OSD) are highly prevalent,
affecting millions globally. While conventional treatments offer some level of success, they …