Lipid nanoparticles as delivery vehicles for inhaled therapeutics

EWX Leong, R Ge - Biomedicines, 2022 - mdpi.com
Lipid nanoparticles (LNPs) have emerged as a powerful non-viral carrier for drug delivery.
With the prevalence of respiratory diseases, particularly highlighted by the current COVID-19 …

Targeting aging pathways in chronic obstructive pulmonary disease

M Easter, S Bollenbecker, JW Barnes… - International journal of …, 2020 - mdpi.com
Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the
third leading cause of death worldwide. COPD is characterized by chronic airway …

FLIGHT1 and FLIGHT2: efficacy and safety of QVA149 (indacaterol/glycopyrrolate) versus its monocomponents and placebo in patients with chronic obstructive …

DA Mahler, E Kerwin, T Ayers… - American journal of …, 2015 - atsjournals.org
Rationale: Current Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy
recommends the combination of two long-acting bronchodilators of different pharmacologic …

Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases

J Garth, JW Barnes, S Krick - International journal of molecular sciences, 2018 - mdpi.com
Cytokines are key players in the initiation and propagation of inflammation in chronic
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …

β2‐adrenoceptor agonists: current and future direction

M Cazzola, L Calzetta… - British journal of …, 2011 - Wiley Online Library
Despite the passionate debate over the use of β2‐adrenoceptor agonists in the treatment of
airway disorders, these agents are still central in the symptomatic management of asthma …

How do dual long-acting bronchodilators prevent exacerbations of chronic obstructive pulmonary disease?

KM Beeh, PR Burgel, FME Franssen… - American journal of …, 2017 - atsjournals.org
Decreasing the frequency and severity of exacerbations is one of the main goals of
treatment for patients with chronic obstructive pulmonary disease. Several studies have …

[HTML][HTML] Long-acting inhaled medicines: present and future

C Zhang, D D'Angelo, F Buttini, M Yang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Inhaled medicines continue to be an essential part of treatment for respiratory diseases such
as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In addition, inhalation …

The complex association between COPD and COVID-19

NT Awatade, PAB Wark, ASL Chan… - Journal of Clinical …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and
mortality worldwide. There is mounting evidence suggesting that COPD patients are at …

Health-related quality of life and its associated factors in patients with chronic obstructive pulmonary disease

AS Jarab, W Al-Qerem, KH Alzoubi, S Abu Heshmeh… - Plos one, 2023 - journals.plos.org
Objective The present study aimed to evaluate HRQOL and to explore the factors associated
with poor HRQOL among patients with COPD. Methods In the present cross-sectional study …

Salmeterol Xinafoate (SX) loaded into mucoadhesive solid lipid microparticles for COPD treatment

E Amore, ML Manca, M Ferraro, D Valenti… - International Journal of …, 2019 - Elsevier
Chronic obstructive pulmonary disease (COPD) is one of the main health problems
worldwide. It is characterised by chronic inflammation in the lungs that leads to progressive …