The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

Interleukin 1 (IL 1), IL 6, and tumor necrosis factor (TNF) are typical examples of
multifunctional cytokines involved in the regulation of the immune response, hematopoiesis …

Interleukin-1 (IL-1) interacts with cells through two types of binding molecules, IL-1 type I
receptor (IL-1R I) and IL-1R II. The function of IL-1R II is unknown. In studies using …

Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned
by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate …

cDNA clones corresponding to an Mr approximately 80,000 receptor (type I receptor) for
interleukin‐1 (IL‐1) have been isolated previously by mammalian expression. Here, we …

A monoclonal antibody (mAb) was isolated that blocked the binding and bioactivity of both
human and murine interleukin 1β (IL-1β) on murine IL-1 receptor-bearing cells. This mAb …

Interleukins (ILs) 1 alpha and 1 beta are important components of the neuroimmune axis.
Recent work has shown that human 125I-IL-1 alpha can enter the brain from the blood by a …

Two receptors for the proinflammatory cytokine interleukin 1 (IL-1) have been cloned and
characterized biochemically. While it has been well established that the type I (80-kDa) IL-1 …

Human monocytes cultured on adherent IgG produce a specific IL-1 inhibitor that functions
as a receptor antagonist (IL-1ra). This molecular has been purified, sequenced, cloned as a …

A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor
antagonist protein (IRAP) which was purified and partially sequenced. A complementary …