Hyaluronan in respiratory injury and repair

GM Turino, JO Cantor - American journal of respiratory and critical …, 2003 - atsjournals.org
Over the past two decades, much of the research on the cellular hyaluronic acid as the
terminology. HA is a naturally occurring, and biochemical reactions to injurious agents of the …

Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma

J Bousquet, P Chanez, JY Lacoste, I Enander… - Journal of allergy and …, 1991 - Elsevier
Bronchial inflammation is a characteristic of asthma that may be examined indirectly by
bronchoalveolar lavage (BAL). Nine normal individuals were compared with 38 age …

Effect of composition of lung biomimetic niche on the mesenchymal stem cell differentiation toward alveolar type II pneumocytes

F Della Sala, M di Gennaro, G Lista… - Macromolecular …, 2023 - Wiley Online Library
Pulmonary niche dynamically orchestrates the signals, such as proliferation or differentiation
of mesenchymal stem cells (MSCs), which allows inducing tissue repair. Lung niche …

Bench-to-bedside review: the role of glycosaminoglycans in respiratory disease

AB Souza-Fernandes, P Pelosi, PRM Rocco - Critical Care, 2006 - Springer
The extracellular matrix (ECM) plays a significant role in the mechanical behaviour of the
lung parenchyma. The ECM is composed of a three-dimensional fibre mesh that is filled with …

Is asthma a fibrotic disease?

CR Roberts - Chest, 1995 - journal.chestnet.org
D amatic changes in the architecture of the airway walls have been described in severe
and/or fatal asthma. Major goals in asthma research include the determination of …

Accumulation of hyaluronan and tissue edema in experimental myocardial infarction.

A Waldenström, HJ Martinussen… - The Journal of …, 1991 - Am Soc Clin Investig
Experimental myocardial infarction was induced in rats. The myocardial accumulation of
hyaluronan (HA) and water during the development of infarction was measured. The …

Development of lung edema: interstitial fluid dynamics and molecular structure

G Miserocchi, D Negrini, A Passi, G De Luca - Physiology, 2001 - journals.physiology.org
Pulmonary interstitium is maintained dehydrated at subatmospheric pressure (–10 cmH2O)
through low capillary permeability, low tissue compliance, and an efficient lymphatic …

Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity

A Hoarau, M Polette, C Coraux - Biomolecules, 2022 - mdpi.com
Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …

Hyaluronic acid improves “pleasantness” and tolerability of nebulized hypertonic saline in a cohort of patients with cystic fibrosis

P Buonpensiero, F De Gregorio, A Sepe… - Advances in …, 2010 - Springer
Introduction Inhaled hypertonic saline improves lung function and decreases pulmonary
exacerbations in people with cystic fibrosis. However, side effects such as cough, narrowing …

Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis

K Mikecz, K Dennis, M Shi… - Arthritis & Rheumatism …, 1999 - Wiley Online Library
Objective To determine how in vivo modulation of CD44 function by antibodies influences
disease severity in a murine model of rheumatoid arthritis. Methods Mice with proteoglycan …