Advances in bladder cancer biology and therapy
The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …
generation sequencing has identified the genes most mutated in bladder cancer. This …
[HTML][HTML] Immunotherapy in small cell lung cancer
G Esposito, G Palumbo, G Carillio, A Manzo… - Cancers, 2020 - mdpi.com
Simple Summary Small cell lung cancer (SCLC) accounts for about 15% of lung cancers
and it has limited therapeutic options and poor prognosis. There has been no real progress …
and it has limited therapeutic options and poor prognosis. There has been no real progress …
Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with αPD‐L1 for enhanced cancer immunotherapy
B Guo, F Yang, L Zhang, Q Zhao, W Wang… - Advanced …, 2023 - Wiley Online Library
Cuproptosis is a new cell death that depends on copper (Cu) ionophores to transport Cu into
cancer cells, which induces cell death. However, existing Cu ionophores are small …
cancer cells, which induces cell death. However, existing Cu ionophores are small …
[HTML][HTML] Cuproptosis scoring system to predict the clinical outcome and immune response in bladder cancer
Q Song, R Zhou, F Shu, W Fu - Frontiers in immunology, 2022 - frontiersin.org
Cuproptosis is a novel copper ion-dependent cell death type being regulated in cells, and
this is quite different from the common cell death patterns such as apoptosis, pyroptosis …
this is quite different from the common cell death patterns such as apoptosis, pyroptosis …
[HTML][HTML] Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments
C Yang, S Wu, Z Mou, Q Zhou, X Dai, Y Ou, X Chen… - Molecular Therapy, 2022 - cell.com
Circular RNAs (circRNAs) play critical roles in different diseases. Exosomes are important
intermediates of intercellular communication. While both have been widely reported in …
intermediates of intercellular communication. While both have been widely reported in …
The dynamic roles of the bladder tumour microenvironment
YC Lee, HM Lam, C Rosser, D Theodorescu… - Nature Reviews …, 2022 - nature.com
Bladder cancer is a prevalent but currently understudied cancer type and patient outcomes
are poor when it progresses to the muscle-invasive stage. Current research in bladder …
are poor when it progresses to the muscle-invasive stage. Current research in bladder …
Immune landscape after allo-HSCT: TIGIT-and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse
V Gournay, N Vallet, V Peux, K Vera… - Blood, The Journal …, 2022 - ashpublications.org
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …
[HTML][HTML] Immunosuppressive tumor-associated macrophages expressing interlukin-10 conferred poor prognosis and therapeutic vulnerability in patients with muscle …
Y Xu, H Zeng, K Jin, Z Liu, Y Zhu, L Xu… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Tumor-associated macrophages (TAMs) secreting IL-10 could be a specific
functional cell subset with distinct polarization state and suppressive role in antitumor …
functional cell subset with distinct polarization state and suppressive role in antitumor …
TOX-expressing terminally exhausted tumor-infiltrating CD8+ T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer
HS Han, S Jeong, H Kim, HD Kim, AR Kim, M Kwon… - Cancer letters, 2021 - Elsevier
Exhausted T cells in the tumor microenvironment are major targets of immunotherapies.
However, the exhaustion status of CD8+ tumor-infiltrating lymphocytes (TILs) in bladder …
However, the exhaustion status of CD8+ tumor-infiltrating lymphocytes (TILs) in bladder …
[PDF][PDF] The tumor microenvironment and immunotherapy in prostate and bladder cancer
Acknowledgements: The authors wish to thank Sima Rabinowitz, SR for editorial assistance.
The authors wish to acknowledge funding support from the Deane Prostate Health, ISMMS …
The authors wish to acknowledge funding support from the Deane Prostate Health, ISMMS …