Cancer has become the silent killer in less-developed countries and the most significant
cause of morbidity worldwide. The accessible and frequently used treatments include …

The methoxy substituent is prevalent in natural products and, consequently, is present in
many natural product-derived drugs. It has also been installed in modern drug molecules …

Background The present study (VINGEM) is the first randomised trial comparing
vinflunine/gemcitabine (VG) to standard carboplatin/gemcitabine (CG) in patients with …

Trichostatin A (TSA), an antifungal antibiotic derived from Streptomyces, inhibits mammalian
histone deacetylases, and especially, selectively inhibits class I and II histone deacetylase …

Simple Summary With the introduction of immune checkpoint inhibitors (ICI) in recent years,
the treatment landscape of metastatic urothelial cancer has undergone a substantial …

Throughout history, naturally derived molecules have had countless applications in
medicine, pharmacy, and biology. This rich reservoir of natural compounds demonstrated …

Simple Summary Few metastatic urothelial cancer patients achieve durable clinical benefit
with vinflunine. Predictive biomarkers to help to identify better treatment strategies are …

Background Vinflunine (VFL) is approved in Europe as second-line treatment of metastatic
urothelial cancer after failure of platinum-containing therapy. We performed a systematic …

Míšek, V.: Izolace alkaloidů Vinca minor a jejich biologická aktivita II. Diplomová práce,
Farmaceutická fakulta v Hradci Králové, Univerzita Karlova, Katedra farmakognozie a …

Background: Several single chemotherapeutic agents have been evaluated as the second-
line treatment of advanced urothelial carcinoma. Despite encouraging efficacy outcomes …