As one of the cornerstones of innate immunity, the complement system has long been
implicated in the pathogenesis of atherosclerosis. Growing evidence demonstrates the …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Stroke is a leading cause of death and disability worldwide and an increasing number of
ischemic stroke patients are undergoing pharmacological and mechanical reperfusion. Both …

Complement is implicated in the pathogenesis of rheumatoid arthritis (RA); elevated levels
of complement activation products have been measured in plasma, synovial fluid, and …

Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture
of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. Despite its …

Eur J Clin Invest 2012; 42 (9): 921–926 Abstract Background Humoral mediators of
inflammation, in particular the complement system, have been described to play an …

Inflammation is the mainstay of atherosclerosis and is an important governing factor at all
stages of the disease process from lesion formation to plaque build-up and final end-stage …

Aim: To investigate the association of Osteopontin (OPN) gene polymorphism and serum
thrombin-cleaved OPN level with the susceptibility to ischemic stroke (IS) and its prognosis …

Intracerebral hemorrhage (ICH) accounts for 10% to 15% of all strokes and is a major cause
of morbidity and mortality. Despite advances in management, numerous clinical trials have …

Background Complement component 5a (C5a) is a highly potent anaphylatoxin with a
variety of pro-inflammatory effects. C5a contributes to progression of atherosclerosis and …