The skeletal muscle Ca2+ release channel, also known as ryanodine receptor type 1
(RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle …

Loss of dystrophin leads to Duchenne muscular dystrophy (DMD). A pathogenic feature of
DMD is the significant elevation of cytosolic calcium. Supraphysiological calcium triggers …

Muscular dystrophies (MDs) are heterogeneous diseases, characterized by primary wasting
of skeletal muscle, which in severe cases, such as Duchenne Muscular Dystrophy (DMD) …

Of the many crucial functions of the ER, homeostasis of physiological calcium increase is
critical for signaling. Plasma membrane (PM) injury causes a pathological calcium influx …

Mineralocorticoid receptor antagonists (MRAs) slow cardiomyopathy in patients with
Duchenne muscular dystrophy (DMD) and improve skeletal muscle pathology and function …

Background Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction
(ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy …

The study of chromatin accessibility across tissues and developmental stages is essential for
elucidating the transcriptional regulation of various phenotypes and biological processes …

Limb-girdle muscular dystrophy recessive 1 (LGMDR1), previously known as LGMD2A, is a
rare disease caused by mutations in the CAPN3 gene. It is characterized by progressive …

Background The dystrophin-glycoprotein complex (DGC) is a critical adhesion complex of
the muscle cell membrane, providing a mechanical link between the extracellular matrix …

Duchenne muscular dystrophy (DMD) is the most severe form of muscular dystrophy
affecting 1 in 3500 live male births. Although there is no cure for DMD, therapeutic strategies …