Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle
JT Olthoff, A Lindsay, R Abo-Zahrah… - Nature …, 2018 - nature.com
Force loss in skeletal muscle exposed to eccentric contraction is often attributed to injury. We
show that EDL muscles from dystrophin-deficient mdx mice recover 65% of lost force within …
show that EDL muscles from dystrophin-deficient mdx mice recover 65% of lost force within …
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
VA Fajardo, E Bombardier, E McMillan… - Disease models & …, 2015 - journals.biologists.com
Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically
characterized by centrally located nuclei, central aggregation of oxidative activity, and type I …
characterized by centrally located nuclei, central aggregation of oxidative activity, and type I …
[HTML][HTML] Sarcomeric deficits underlie MYBPC1-associated myopathy with myogenic tremor
JG Hauserman, J Stavusis, HC Joca, JC Robinett… - JCI insight, 2021 - ncbi.nlm.nih.gov
Myosin binding protein-C slow (sMyBP-C) comprises a subfamily of cytoskeletal proteins
encoded by MYBPC1 that is expressed in skeletal muscles where it contributes to myosin …
encoded by MYBPC1 that is expressed in skeletal muscles where it contributes to myosin …
Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin–NFAT signaling in skeletal muscle of DM1 mice
A Ravel-Chapuis, G Bélanger, J Côté… - Human Molecular …, 2017 - academic.oup.com
Abstract Myotonic Dystrophy type 1 (DM1) is caused by an expansion of CUG repeats in
DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA …
DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA …
Curcumin Administration Improves Force of mdx Dystrophic Diaphragm by Acting on Fiber-Type Composition, Myosin Nitrotyrosination and SERCA1 Protein Levels
L Gorza, E Germinario, M Vitadello, I Guerra, F De Majo… - Antioxidants, 2023 - mdpi.com
The vegetal polyphenol curcumin displays beneficial effects against skeletal muscle
derangement induced by oxidative stress, disuse or aging. Since oxidative stress and …
derangement induced by oxidative stress, disuse or aging. Since oxidative stress and …
The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse
OA Bahri, N Naldaiz-Gastesi, DC Kennedy… - Scientific Reports, 2019 - nature.com
The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with
remnants in humans, is highly regenerative, and whose function is purported to be linked to …
remnants in humans, is highly regenerative, and whose function is purported to be linked to …
Variable cytoplasmic actin expression impacts the sensitivity of different dystrophin‐deficient mdx skeletal muscles to eccentric contraction
Eccentric contractions (ECCs) induce force loss in several skeletal muscles of dystrophin‐
deficient mice (mdx), with the exception of the soleus (Sol). The eccentric force: isometric …
deficient mice (mdx), with the exception of the soleus (Sol). The eccentric force: isometric …
Measurement of skeletal muscle fiber contractility with high-speed traction microscopy
M Rausch, D Böhringer, M Steinmann, DW Schubert… - Biophysical journal, 2020 - cell.com
We describe a technique for simultaneous quantification of the contractile forces and
cytosolic calcium dynamics of muscle fibers embedded in three-dimensional biopolymer …
cytosolic calcium dynamics of muscle fibers embedded in three-dimensional biopolymer …
[HTML][HTML] NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression
A Boulinguiez, C Duhem, A Mayeuf-Louchart… - JCI insight, 2022 - ncbi.nlm.nih.gov
The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR
calcium mishandling is described in pathological conditions, such as myopathies. Here, we …
calcium mishandling is described in pathological conditions, such as myopathies. Here, we …
DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants
C Scholtes, S Bellemin, E Martin, M Carre-Pierrat… - Scientific reports, 2018 - nature.com
Mitochondria are double-membrane subcellular organelles with highly conserved metabolic
functions including ATP production. Mitochondria shapes change continually through the …
functions including ATP production. Mitochondria shapes change continually through the …