Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

JT Olthoff, A Lindsay, R Abo-Zahrah… - Nature …, 2018 - nature.com
Force loss in skeletal muscle exposed to eccentric contraction is often attributed to injury. We
show that EDL muscles from dystrophin-deficient mdx mice recover 65% of lost force within …

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype

VA Fajardo, E Bombardier, E McMillan… - Disease models & …, 2015 - journals.biologists.com
Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically
characterized by centrally located nuclei, central aggregation of oxidative activity, and type I …

[HTML][HTML] Sarcomeric deficits underlie MYBPC1-associated myopathy with myogenic tremor

JG Hauserman, J Stavusis, HC Joca, JC Robinett… - JCI insight, 2021 - ncbi.nlm.nih.gov
Myosin binding protein-C slow (sMyBP-C) comprises a subfamily of cytoskeletal proteins
encoded by MYBPC1 that is expressed in skeletal muscles where it contributes to myosin …

Misregulation of calcium-handling proteins promotes hyperactivation of calcineurin–NFAT signaling in skeletal muscle of DM1 mice

A Ravel-Chapuis, G Bélanger, J Côté… - Human Molecular …, 2017 - academic.oup.com
Abstract Myotonic Dystrophy type 1 (DM1) is caused by an expansion of CUG repeats in
DMPK mRNAs. This mutation affects alternative splicing through misregulation of RNA …

Curcumin Administration Improves Force of mdx Dystrophic Diaphragm by Acting on Fiber-Type Composition, Myosin Nitrotyrosination and SERCA1 Protein Levels

L Gorza, E Germinario, M Vitadello, I Guerra, F De Majo… - Antioxidants, 2023 - mdpi.com
The vegetal polyphenol curcumin displays beneficial effects against skeletal muscle
derangement induced by oxidative stress, disuse or aging. Since oxidative stress and …

The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse

OA Bahri, N Naldaiz-Gastesi, DC Kennedy… - Scientific Reports, 2019 - nature.com
The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with
remnants in humans, is highly regenerative, and whose function is purported to be linked to …

Variable cytoplasmic actin expression impacts the sensitivity of different dystrophin‐deficient mdx skeletal muscles to eccentric contraction

A Lindsay, WM Southern, PM McCourt… - The FEBS …, 2019 - Wiley Online Library
Eccentric contractions (ECCs) induce force loss in several skeletal muscles of dystrophin‐
deficient mice (mdx), with the exception of the soleus (Sol). The eccentric force: isometric …

Measurement of skeletal muscle fiber contractility with high-speed traction microscopy

M Rausch, D Böhringer, M Steinmann, DW Schubert… - Biophysical journal, 2020 - cell.com
We describe a technique for simultaneous quantification of the contractile forces and
cytosolic calcium dynamics of muscle fibers embedded in three-dimensional biopolymer …

[HTML][HTML] NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression

A Boulinguiez, C Duhem, A Mayeuf-Louchart… - JCI insight, 2022 - ncbi.nlm.nih.gov
The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR
calcium mishandling is described in pathological conditions, such as myopathies. Here, we …

DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants

C Scholtes, S Bellemin, E Martin, M Carre-Pierrat… - Scientific reports, 2018 - nature.com
Mitochondria are double-membrane subcellular organelles with highly conserved metabolic
functions including ATP production. Mitochondria shapes change continually through the …