Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy
Colorectal cancer (CRC) is the third most common cancer and has the second highest
mortality rate among cancers. The development of CRC involves both genetic and …
mortality rate among cancers. The development of CRC involves both genetic and …
Regulation of inflammatory diseases via the control of mRNA decay
M Yoshinaga, O Takeuchi - Inflammation and Regeneration, 2024 - Springer
Inflammation orchestrates a finely balanced process crucial for microorganism elimination
and tissue injury protection. A multitude of immune and non-immune cells, alongside various …
and tissue injury protection. A multitude of immune and non-immune cells, alongside various …
[HTML][HTML] Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1
Y Hirata, Y Nakata, H Komatsu, Y Kudoh… - Free Radical Biology …, 2024 - Elsevier
Reactive oxygen species (ROS) are highly reactive and their accumulation causes oxidative
damage to cells. Cells maintain survival upon mild oxidative stress with anti-oxidative …
damage to cells. Cells maintain survival upon mild oxidative stress with anti-oxidative …
Crosstalk between Regnase-1 and-3 shapes mast cell survival and cytokine expression
M Bataclan, C Leoni, SG Moro… - Life Science …, 2024 - life-science-alliance.org
Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins
(RBPs) impacts immune cell responses, including mast cell functionality. Despite their …
(RBPs) impacts immune cell responses, including mast cell functionality. Despite their …
RNA metabolism governs immune function and response
M Yoshinaga, O Takeuchi - Basic Immunology and Its Clinical Application, 2024 - Springer
Inflammation is a complex process that protects our body from various insults such as
infection, injury, and stress. Proper inflammation is beneficial to eliminate the insults and …
infection, injury, and stress. Proper inflammation is beneficial to eliminate the insults and …
[HTML][HTML] Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells
JK Wiencke, E Nissen, DC Koestler, SJ Tamaki… - Research …, 2023 - ncbi.nlm.nih.gov
Glioblastomas (GBM) are lethal central nervous system cancers associated with tumor and
systemic immunosuppression. Heterogeneous monocyte myeloid-derived suppressor cells …
systemic immunosuppression. Heterogeneous monocyte myeloid-derived suppressor cells …
Ubiquitin-specific protease 8 controls B-cell proteostasis and survival representing a target in multiple myeloma
A Dufner, F Thery, G Monaco, J Lazarevic, O Gorka… - bioRxiv, 2024 - biorxiv.org
Ubiquitin-specific protease 8 is involved in endosomal/lysosomal trafficking, exerts multiple
cellular functions, and was identified as a vulnerability gene for multiple myeloma, a disease …
cellular functions, and was identified as a vulnerability gene for multiple myeloma, a disease …
Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment
Recently, considerable attention has been directed toward innate-like T cells (ITCs) and
innate lymphoid cells (ILCs) owing to their indispensable contributions to immune …
innate lymphoid cells (ILCs) owing to their indispensable contributions to immune …
Crosstalk between the RNA-binding proteins Regnase-1 and-3 shapes mast cell survival and cytokine expression
M Bataclan, C Leoni, SG Moro, M Pecoraro, EH Wong… - bioRxiv, 2024 - biorxiv.org
Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins
(RBPs) impacts immune cell responses, including mast cell functionality. Despite their …
(RBPs) impacts immune cell responses, including mast cell functionality. Despite their …