Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Lipodystrophy is a medical condition characterized by complete or partial loss of adipose
tissue. Not infrequently, lipodystrophy occurs in combination with pathological accumulation …

The treatment of metabolic disease is becoming an increasingly important component of the
long-term management of patients with well controlled HIV on antiretroviral therapy (ART) …

Leptin has emerged over the past decade as a key hormone in not only the regulation of
food intake and energy expenditure but also in the regulation of neuroendocrine and …

Objectives: Plasma soluble inflammatory molecules are associated with the risk of ischaemic
cardiovascular events. We investigated whether HIV replication modified the levels of these …

OBJECTIVE: Adipokines are fat-derived hormones and cytokines with immune-modulating
and metabolic properties. Most of them are associated with insulin resistance. The aim of the …

HIV-1/highly active antiretroviral therapy-associated lipodystrophy syndrome (HALS) is an
adipose tissue redistribution disorder characterized by subcutaneous adipose tissue …

Leptin is a hormone secreted by adipocytes that regulates energy metabolism via peripheral
action on glucose synthesis and utilization as well as through central regulation of food …

Background Lipodystrophies are characterized by adipose tissue redistribution, insulin
resistance (IR) and metabolic complications. Adipokines and hormones related to body …

Severe insulin resistance syndromes are a heterogeneous group of rare disorders
characterized by profound insulin resistance, substantial metabolic abnormalities, and a …