Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

In this in-depth review, we examine the worldwide epidemiology of SLE and summarize
current knowledge on the influence of race/ethnicity on clinical manifestations, disease …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

A historical tendency to use European ancestry samples hinders medical genetics research,
including the use of polygenic scores, which are individual-level metrics of genetic risk. We …

Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese
individuals and performed further transancestry meta-analyses with data from the Psychiatry …

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using …

Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been
associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …