Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera - Pharmacological Reviews, 2012 - ASPET
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD

M Cazzola, M Molimard - Pulmonary pharmacology & therapeutics, 2010 - Elsevier
Bronchodilators are the cornerstone of pharmacological management of COPD. For patients
whose conditions are not sufficiently controlled by monotherapy, combining bronchodilators …

Single inhaler extrafine triple therapy versus long-acting muscarinic antagonist therapy for chronic obstructive pulmonary disease (TRINITY): a double-blind, parallel …

J Vestbo, A Papi, M Corradi, V Blazhko, I Montagna… - The Lancet, 2017 - thelancet.com
Background Limited data are available for the efficacy of triple therapy with two long-acting
bronchodilators and an inhaled corticosteroid in chronic obstructive pulmonary disease …

[HTML][HTML] The Saudi Initiative for Asthma-2021 Update: Guidelines for the diagnosis and management of asthma in adults and children

MS Al-Moamary, SA Alhaider, AA Alangari… - Annals of thoracic …, 2021 - journals.lww.com
Abstract The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma
guidelines for the diagnosis and management of asthma for adults and children, which is …

β2‐adrenoceptor agonists: current and future direction

M Cazzola, L Calzetta… - British journal of …, 2011 - Wiley Online Library
Despite the passionate debate over the use of β2‐adrenoceptor agonists in the treatment of
airway disorders, these agents are still central in the symptomatic management of asthma …

Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD

BC Moulton, AD Fryer - British journal of pharmacology, 2011 - Wiley Online Library
In the lungs, parasympathetic nerves provide the dominant control of airway smooth muscle
with release of acetylcholine onto M3 muscarinic receptors. Treatment of airway disease …

Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy

L Calzetta, MG Matera, M Cazzola - European journal of pharmacology, 2015 - Elsevier
Nowadays there is solid clinical information for combining β 2-agonists and anti-muscarinic
agents, although the nature (additive or synergistic) of the net clinical result obtained by co …

The Saudi Initiative for Asthma-2019 Update: Guidelines for the diagnosis and management of asthma in adults and children

MS Al-Moamary, SA Alhaider, AA Alangari… - Annals of thoracic …, 2019 - journals.lww.com
This is the fourth version of the updated guidelines for the diagnosis and management of
asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi …

[HTML][HTML] Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents

DP Tashkin, LM Fabbri - Respiratory research, 2010 - Springer
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and debilitating symptoms. For patients with moderate-to-severe COPD, long …

Involvement of α2‐and β2‐adrenoceptors on breast cancer cell proliferation and tumour growth regulation

C Pérez Piñero, A Bruzzone… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE β‐Adrenoceptors are expressed in human and
experimental animal breast cancer cells. However, the effect of the agonists and antagonists …