Phenotyping airways disease: an A to E approach

S Gonem, V Raj, AJ Wardlaw, ID Pavord… - Clinical & …, 2012 - Wiley Online Library
The airway diseases asthma and chronic obstructive pulmonary disease (COPD) are
heterogeneous conditions with overlapping pathophysiological and clinical features. It has …

Sports doping: Emerging designer and therapeutic β2-agonists

AG Fragkaki, C Georgakopoulos, S Sterk… - Clinica chimica acta, 2013 - Elsevier
Beta 2-adrenergic agonists, or β 2-agonists, are considered essential bronchodilator drugs
in the treatment of bronchial asthma, both as symptom-relievers and, in combination with …

Stability-indicating UPLC assay coupled with mass spectrometry for the analysis of vilanterol degradation products in human urine

M Tarek, HA Wagdy, MA Hegazy, NS Ghoniem - Scientific Reports, 2024 - nature.com
Vilanterol is a once-daily dose inhaler prescribed for asthma and chronic obstructive
pulmonary disease. This study involved an investigation of vilanterol stability under acidic …

Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules

AD Hughes, KH Chin, SL Dunham, JR Jasper… - Bioorganic & medicinal …, 2011 - Elsevier
We sought to design dual pharmacology bronchodilators targeting both the M3 muscarinic
acetylcholine and beta-2 adrenergic (β2) receptors by applying our multivalent approach to …

Inhaled muscarinic acetylcholine receptor antagonists for treatment of COPD

P Montuschi, F Macagno, S Valente… - Current Medicinal …, 2013 - ingentaconnect.com
Bronchodilators, generally administered via metered dose or dry powder inhalers, are the
mainstays of pharmacological treatment of stable COPD. Inhaled long-acting beta-agonists …

Ultra long-acting β-agonists in chronic obstructive pulmonary disease

RM Burkes, RJ Panos - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
Introduction Inhaled β-agonists have been foundational medications for maintenance COPD
management for decades. Through activation of cyclic adenosine monophosphate …

Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation

G Damera, M Jiang, H Zhao, HW Fogle… - European journal of …, 2010 - Elsevier
Airway hyperresponsiveness and inflammation characterize the airways of individuals with
asthma and chronic obstructive pulmonary disease (COPD). Hence, therapeutic approaches …

An update on bronchodilators in Phase I and II clinical trials

M Cazzola, P Rogliani, A Segreti… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Inhaled bronchodilators are the mainstay of the current management of COPD
at all stages of the disease, and are critical in the symptomatic management of asthma …

Severe substance use disorder viewed as a chronic condition and disability

LR Goodwin Jr, SM Sias - Journal of rehabilitation, 2014 - search.proquest.com
Severe substance use disorders are increasingly viewed as chronic conditions, much like
diabetes, hypertension, or asthma, requiring profound lifestyle changes and close …

Multivalent dual pharmacology muscarinic antagonist and β2 agonist (MABA) molecules for the treatment of COPD

AD Hughes, A McNamara, T Steinfeld - Progress in medicinal chemistry, 2012 - Elsevier
Abstract Inhaled beta-2-adrenergic receptor (β 2) agonists and inhaled muscarinic
acetylcholine antagonists are the most frequently used bronchodilators in the treatment of …