Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …

After encountering antigen, helper T (TH) cells undergo differentiation to effector cells, which
can secrete high levels of interferon-γ, interleukin-4 (IL-4), IL-10 and other …

Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic
protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 …

Interleukin-27 (IL-27) supports proliferation of naive CD4+ T cells and enhances interferon-γ
(IFN-γ) production by activated T cells and natural killer (NK) cells. We report here that IL-27 …

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular
bacterial pathogens. It is commonly thought that natural killer cells are the primary source of …

IL-18 is a proinflammatory cytokine produced by macrophages and other cell types present
in the kidney during ischemia-reperfusion injury (IRI), but its role in this injury is unknown …

Abstract IFN-λ 1,-λ 2 and-λ 3 have been discovered as the latest members of the class II
cytokine family and shown to possess antiviral activity. Murine B16 melanoma and Colon26 …

Listeria monocytogenes (LM), a facultative intracellular Gram-positive bacterium, often
causes lethal infection of the host. In this study we investigated the molecular mechanism …

We have assessed the requirements for Toll-like receptor (TLR) signaling in vivo during
early infection with Listeria monocytogenes. Mice deficient for TLR2, a receptor required for …