Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly
increases the risk of stroke and dementia. The main pathological changes are vascular, in …

Dilated cardiomyopathy (DCM) is a relatively common heart muscle disease characterized
by the dilation and thinning of the left ventricle accompanied with left ventricular systolic …

Haemorrhagic stroke accounts for∼ 20% of stroke cases and porencephaly is a clinical
consequence of perinatal cerebral haemorrhaging. Here, we report the identification of a …

Cerebral small vessel diseases (SVD) have been causally correlated with ischemic strokes,
leading to cognitive decline and vascular dementia. Neuroimaging and molecular genetic …

Literacy learning depends on the flexibility of the human brain to reconfigure itself in
response to environmental influences. At the same time, literacy and disorders of literacy …

Intracerebral hemorrhage (ICH) is a devastating type of stroke, frequently resulting in
unfavorable functional outcomes. Up to 15% of stroke patients experience ICH and …

Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes.
Collagen type IV alpha 2 (COL4A2), a major component of the basement membrane …

Mutations in COL4A1 have been identified in families with hereditary small vessel disease of
the brain presumably due to a dominant-negative mechanism. Here, we report on two novel …

Abstract COL4A1 and COL4A2 genes encode the alpha1 and the alpha2 chains of type IV
collagen, a key component of basement membranes. Mutations located in the coding …

Type IV collagen is the main collagen component of the basement membrane. It is a network-
forming collagen that underlies epithelial and endothelial cells and functions as a barrier …