Insulin is synthesised as a single-chain precursor, preproinsulin, that contains an N-terminal
signal sequence and a connecting peptide linking the A and B chains of the insulin …

Publisher Summary This chapter reviews the physical, chemical, and biological properties of
insulin in the light of the atomic arrangement found in insulin crystals. It also describes the …

The behaviour of proinsulin and insulin in the presence of zinc suggests it plays an
important role in insulin's production in the B-cell for the vast majority of animal species. The …

The hypothesis advanced in this article requires further validation. Undoubtedly it will
require modification as our knowledge of biochemical control increases. Nevertheless, it …

The central importance of membranes in the organization of the cell has stimulated an
enormous research effort to identify the molecular basis of their structural and functional …

By application of autoradiographic technique the cellular and subcellular distribution of radio-
activity in mouse pancreatic islets was investigated following intravenous administration of 3 …

The possible relationship between cyclic adenosine 3′: 5′-monophosphate (cAMP) and
neurotubules in synaptic transmission has been explored. The neurotubular subunit protein …

Beta granules isolated from rat islets of Langerhans and subjected only to phosphotungstic
acid had, in negatively stained images, a 50-A periodicity. This periodicity was also …

In order to localize 5-hydroxytryptamine (5-HT) stores in the islet of Langerhans of guinea
pig pancreas, a cytochemical procedure for the ultrastructural differentiation between …

The pancreatic islets of the dog, guinea pig and pigeon were studied under the electron
microscope and the following results were obtained. 1. Besides A and B cells, D cells are …