Bromodomains: Structure, function and pharmacology of inhibition

E Ferri, C Petosa, CE McKenna - Biochemical pharmacology, 2016 - Elsevier
Bromodomains are epigenetic readers of histone acetylation involved in chromatin
remodeling and transcriptional regulation. The human proteome comprises 46 …

The role of epigenetics in placental development and the etiology of preeclampsia

C Apicella, CSM Ruano, C Méhats, F Miralles… - International journal of …, 2019 - mdpi.com
In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Disassociation of vitamin D's calcemic activity and non-calcemic genomic activity and individual responsiveness: a randomized controlled double-blind clinical trial

A Shirvani, TA Kalajian, A Song, MF Holick - Scientific reports, 2019 - nature.com
The aims of this randomized controlled double-blind clinical trial were to assess the impact
of vitamin D supplementation on calcium metabolism and non-calcemic broad gene …

Insulin resistance is cheerfully hitched with hypertension

S Sinha, M Haque - Life, 2022 - mdpi.com
Cardiovascular diseases and type 2 diabetes mellitus (T2DM) have risen steadily
worldwide, particularly in low-income and developing countries. In the last hundred years …

Dynamics of epigenetic phenomena: intergenerational and intragenerational phenotype 'washout'

WW Burggren - Journal of Experimental Biology, 2015 - journals.biologists.com
Epigenetic studies of both intragenerational and transgenerational epigenetic phenotypic
modifications have proliferated in the last few decades. However, the strong reductionist …

[HTML][HTML] Effects of Environmental Factors and Epigenetic on Health and the Development of Diseases

M Farrokhi, F Taheri, E Karami, R Khorram… - Kindle, 2023 - preferpub.org
The effects of environmental factors and epigenetics on health and disease development
are complex and interconnected. Environmental factors encompass external influences like …

Maternal epigenetics and fetal and neonatal growth

S Kitsiou-Tzeli, M Tzetis - Current Opinion in Endocrinology …, 2017 - journals.lww.com
Maternal epigenetics and fetal and neonatal growth : Current Opinion in Endocrinology,
Diabetes and Obesity Maternal epigenetics and fetal and neonatal growth : Current Opinion in …

Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest

AF Kebede, R Schneider, S Daujat - The FEBS journal, 2015 - Wiley Online Library
N‐terminal tails of histones are easily accessible outside of the nucleosomal core particle
and post‐translational modifications (PTM s) of these tails have been the focus of attention in …

DNA methylation patterns within whole blood of adolescents born from assisted reproductive technology are not different from adolescents born from natural …

B Penova-Veselinovic, PE Melton… - Human …, 2021 - academic.oup.com
STUDY QUESTION Do the epigenome-wide DNA methylation profiles of adolescents born
from ART differ from the epigenome of naturally conceived counterparts? SUMMARY …

The role of piRNA and its potential clinical implications in cancer

CB Assumpção, DQ Calcagno, TMT Araújo… - …, 2015 - Taylor & Francis
Epigenetic mechanisms work in an orchestrated fashion to control gene expression in both
homeostasis and diseases. Among small noncoding RNAs, piRNAs seem to meet the …